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LY-88329
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    LY-88329

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    LY-88329
    LY88329 structure.png
    Identifiers
    • 3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-1-phenylpropan-1-one
    CAS Number
    PubChem CID
    ChemSpider
    ChEMBL
    Chemical and physical data
    Formula C22H27NO2
    Molar mass 337.463 g·mol−1
    3D model (JSmol)
    • C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CCC(=O)C3=CC=CC=C3
    • InChI=1S/C22H27NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h3-10,15,17,24H,11-14,16H2,1-2H3/t17-,22+/m0/s1
    • Key:IQGJBVSSFDCTAJ-HTAPYJJXSA-N

    LY-88329 is an opioid receptor ligand related to medicines such as pethidine. It has high affinity to the μ-opioid receptor, but unlike structurally related drugs such as 3-methylfentanyl and OPPPP, LY-88329 is a potent opioid antagonist. In animal studies it blocks the effects of morphine and has anorectic action.

    See also




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