Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
Abandoned drugs
Lynestrenol phenylpropionate
Другие языки:

    Lynestrenol phenylpropionate

    Подписчиков: 0, рейтинг: 0
    Lynestrenol phenylpropionate
    Lynestrenol phenylpropionate.svg
    Clinical data
    Other names LPP; 17α-Ethynylestr-4-en-17β-ol 17β-(3-phenylpropionate); 19-Nor-17α-pregn-4-en-20-yn-17-ol benzenepropanoate
    Routes of
    administration    		 Intramuscular injection
    Drug class Progestogen; Progestin; Progestogen ester
    Identifiers
    • [(8R,9S,10R,13S,14S,17R)-17-Ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] 3-phenylpropanoate
    CAS Number
    Chemical and physical data
    Formula C29H36O2
    Molar mass 416.605 g·mol−1
    3D model (JSmol)
    • O(C(CCC1C=CC=CC=1)=O)[C@](C#C)1CC[C@]([H])2[C@@]([H])3CCC4=CCCC[C@]4([H])[C@@]3([H])CC[C@@]21C
    • InChI=1S/C29H36O2/c1-3-29(31-27(30)16-13-21-9-5-4-6-10-21)20-18-26-25-15-14-22-11-7-8-12-23(22)24(25)17-19-28(26,29)2/h1,4-6,9-11,23-26H,7-8,12-20H2,2H3/t23-,24+,25+,26-,28-,29-/m0/s1
    • Key:JOWUABYPVVAHHK-IISZJVLJSA-N

    Lynestrenol phenylpropionate (LPP), also known as ethynylestrenol phenylpropionate, is a progestin and a progestogen ester which was developed for potential use as a progestogen-only injectable contraceptive by Organon but was never marketed. It was assessed at doses of 25 to 75 mg in an oil solution once a month by intramuscular injection. LPP was associated with high contraceptive failure at the low dose and with poor cycle control. The medication was found to produce estrogenic effects in the endometrium in women due to transformation into estrogenic metabolites.

    A single intramuscular injection of 50 to 100 mg LPP in oil solution has been found to have a duration of action of 14 to 30 days in terms of clinical biological effect in the uterus and on body temperature in women.

    LPP has a long biological half-life in rats when given as an intramuscular depot injection; its half-life was similar to that of nandrolone laurate (nandrolone dodecanoate) and was about 2-fold longer than that of nandrolone decanoate, 10-fold longer than that of lynestrenol and nandrolone phenylpropionate, 50-fold longer than that of progesterone, and 430-fold longer than that of nandrolone.

    Parenteral potencies and durations of progestogens
    Compound Form Dose for specific uses (mg) DOA
    TFD POICD CICD
    Algestone acetophenide Oil soln. - – 75–150 14–32 d
    Gestonorone caproate Oil soln. 25–50 – – 8–13 d
    Hydroxyprogest. acetate Aq. susp. 350 – – 9–16 d
    Hydroxyprogest. caproate Oil soln. 250–500 – 250–500 5–21 d
    Medroxyprog. acetate Aq. susp. 50–100 150 25 14–50+ d
    Megestrol acetate Aq. susp. - – 25 >14 d
    Norethisterone enanthate Oil soln. 100–200 200 50 11–52 d
    Progesterone Oil soln. 200 – – 2–6 d
    Aq. soln. ? – – 1–2 d
    Aq. susp. 50–200 – – 7–14 d
    Notes and sources:

    See also


    Новое сообщение