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Mu-opioid receptor agonists
Methoxyacetylfentanyl
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    Methoxyacetylfentanyl

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    Methoxyacetylfentanyl
    Methoxyacetylfentanyl Structure.svg
    Methoxyacetylfentanyl 3D BS.png
    Legal status
    Legal status
    Identifiers
    • 2-Methoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C22H28N2O2
    Molar mass 352.47 g·mol−1
    3D model (JSmol)
    • c3ccccc3N(C(=O)COC)C1CCN(CC1)CCc2ccccc2
    • InChI=1S/C22H28N2O2/c1-26-18-22(25)24(20-10-6-3-7-11-20)21-13-16-23(17-14-21)15-12-19-8-4-2-5-9-19/h2-11,21H,12-18H2,1H3
    • Key:SADNVKRDSWWFTK-UHFFFAOYSA-N

    Methoxyacetylfentanyl, commonly known as MAF is an opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug.

    Side effects

    Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.

    Legal status

    Methoxyacetylfentanyl was placed into Schedule I in the US in October 2017, in order to avoid an imminent hazard to public safety.

    See also


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