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N-Terminal domain antiandrogen
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    N-Terminal domain antiandrogen

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    N-Terminal domain antiandrogen
    Drug class
    EPI-001.svg
    EPI-001, the first major N-terminal domain AR antagonist to be developed.
    Class identifiers
    Synonyms N-Terminal domain AR antagonists; AR NTD antagonists
    Use Prostate cancer
    Biological target Androgen receptor
    In Wikidata

    N-Terminal domain antiandrogens are a novel type of antiandrogen that bind to the N-terminal domain of the androgen receptor (AR) instead of the ligand-binding domain (where all currently-available antiandrogens bind) and disrupt interactions between the AR and its coregulatory binding partners, thereby blocking AR-mediated gene transcription. They are being investigated for the treatment of prostate cancer.

    See also



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