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Mu-opioid receptor agonists
NFEPP
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NFEPP

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NFEPP
Nfepp.png
Clinical data
Drug class Opioid
Legal status
Legal status
Identifiers
  • N-(3-Fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide
CAS Number
ChemSpider
UNII
Chemical and physical data
Formula C22H27FN2O
Molar mass 354.469 g·mol−1
3D model (JSmol)
  • CCC(=O)N(c1ccccc1)[C@H]2CCN(C[C@H]2F)CCc3ccccc3
  • InChI=1S/C22H27FN2O/c1-2-22(26)25(19-11-7-4-8-12-19)21-14-16-24(17-20(21)23)15-13-18-9-5-3-6-10-18/h3-12,20-21H,2,13-17H2,1H3/t20-,21+/m1/s1
  • Key:DMCQJJAWMFBPOX-RTWAWAEBSA-N

NFEPP (N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide) is an analgesic opioid chemical, similar in structure to fentanyl, designed in 2016 by Spahn et al. from Free University of Berlin to avoid the standard negative side effects of opiates, including opioid overdose, by only targeting inflamed tissue.

Inflamed tissue

Inflamed tissue has a lower pH value (~5–7) than non-inflamed tissue (7.4). Through computer simulation, scientists found a way to make the fentanyl analog only affect inflamed tissue via the addition of fluorine to the chemical structure. In experiment, it was shown that NFEPP produced injury-restricted analgesia in rats with different types of inflammatory pain without exhibiting typical opiate effects, including respiratory depression, sedation, constipation, and chemical seeking behavior.

As a result, NFEPP has the potential to reduce opioid addiction and dependency, as there is no effect on users who are not actually suffering from pain, as the chemical does not interact with non-inflamed brain tissue until much higher doses are reached.


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