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Oxymorphol
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    Oxymorphol

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    Oxymorphol
    Oxymorphol Structure.svg
    Clinical data
    Other names 4,5α-Epoxy-17-methylmorphinan-3,6,14-triol
    ATC code
    Pharmacokinetic data
    Metabolism hepatic
    Identifiers
    • (5α)-17-Methyl-4,5-epoxymorphinan-3,6,14-triol
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C17H21NO4
    Molar mass 303.358 g·mol−1
    3D model (JSmol)
    • CN1CC[C@]23c4c5ccc(c4O[C@H]2C(CC[C@]3([C@H]1C5)O)O)O
    • InChI=1S/C17H21NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,11-12,15,19-21H,4-8H2,1H3/t11?,12-,15+,16+,17-/m1/s1 checkY
    • Key:AABLHGPVOULICI-ZOFKVTQNSA-N checkY

    Oxymorphol is oxymorphone which has been hydrogenated at the 6-position and consists of a mixture of 4,5α-Epoxy-17-methylmorphinan-3,6β,14-triol and 4,5α-Epoxy-17-methylmorphinan-3,6α,14-triol (hydromorphinol). It is produced by the human body as an active metabolite of oxymorphone and some bacteria as an intermediate in turning morphine into hydromorphone. It can also be manufactured and is the subject of patents by drug companies looking for new semi-synthetic analgesics and cough suppressants.

    A derivative of oxymorphol, 8-hydroxy-6-α-oxymorphol, was discovered in the first decade of the 21st century and the subject of a patent application by Endo Pharmaceuticals for an analgesic and antitussive.


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