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Mu-opioid receptor agonists
Pericine
Другие языки:

Pericine

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Pericine
Pericine.svg
Names
IUPAC name
(1R,16E)-16-Ethylidene-2-methylene-4,14-diazatetracyclo[12.2.2.03,11.05,10]octadeca-3(11),5,7,9-tetraene
Other names
Subincanadine E
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
UNII
  • InChI=1S/C19H22N2/c1-3-14-12-21-10-8-15(14)13(2)19-17(9-11-21)16-6-4-5-7-18(16)20-19/h3-7,15,20H,2,8-12H2,1H3/b14-3-/t15-/m0/s1
    Key: VAUGOKMDSLQYNG-WNDJQJCJSA-N
  • C/C=C\1/CN2CCc3c4ccccc4[nH]c3C(=C)[C@@H]1CC2
Properties
C19H22N2
Molar mass 278.399 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pericine is one of a number of indole alkaloids found in the tree Picralima nitida, commonly known as akuamma. As with some other alkaloids from this plant such as akuammine, pericine has been shown to bind to mu opioid receptors in vitro, and has an IC50 of 0.6 μmol, within the range of a weak analgesic. It may also have convulsant effects.

Pericine has been prepared in the laboratory by total synthesis.

See also


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