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Pfizer brands
PF-4455242
Другие языки:

    PF-4455242

    Подписчиков: 0, рейтинг: 0
    PF-4455242
    PF-4455242.svg
    Clinical data
    Routes of
    administration    		 Oral
    ATC code
    • None
    Identifiers
    • 2-Methyl-N-{[2’-(1-pyrrolidinylsulfonyl)-4-biphenylyl]methyl}-1-propanamine
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C21H28N2O2S
    Molar mass 372.53 g·mol−1
    3D model (JSmol)
    • CC(C)CNCC1=CC=C(C=C1)C2=CC=CC=C2S(=O)(=O)N3CCCC3
    • InChI=1S/C21H28N2O2S/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3
    • Key:OWVIKBRKPCTDEP-UHFFFAOYSA-N

    PF-4455242 is a selective, short-acting (non-"inactivating") antagonist of the κ-opioid receptor. Discovered by Pfizer in 2009, it was pursued in a phase I clinical trial for the treatment of bipolar disorder, and was also investigated as a treatment for depression and substance abuse. However, development was stopped in September 2010 due to toxicology findings in animals that had been exposed to the drug for three months.

    See also

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