|
|
mAChRs |
Agonists |
|
Antagonists |
- 3-Quinuclidinyl benzilate
- 4-DAMP
-
Aclidinium bromide (+formoterol)
- Abediterol
- AF-DX 250
- AF-DX 384
- Ambutonium bromide
- Anisodamine
- Anisodine
-
Antihistamines (first-generation) (e.g., brompheniramine, buclizine, captodiame, chlorphenamine (chlorpheniramine), cinnarizine, clemastine, cyproheptadine, dimenhydrinate, dimetindene, diphenhydramine, doxylamine, meclizine, mequitazine, perlapine, phenindamine, pheniramine, phenyltoloxamine, promethazine, propiomazine, triprolidine)
- AQ-RA 741
- Atropine
- Atropine methonitrate
-
Atypical antipsychotics (e.g., clozapine, fluperlapine, olanzapine (+fluoxetine), rilapine, quetiapine, tenilapine, zotepine)
- Benactyzine
- Benzatropine (benztropine)
- Benzilone
- Benzilylcholine mustard
- Benzydamine
- BIBN 99
- Biperiden
- Bornaprine
- Camylofin
- CAR-226,086
- CAR-301,060
- CAR-302,196
- CAR-302,282
- CAR-302,368
- CAR-302,537
- CAR-302,668
- Caramiphen
- Cimetropium bromide
- Clidinium bromide
- Cloperastine
- CS-27349
- Cyclobenzaprine
- Cyclopentolate
- Darifenacin
- DAU-5884
- Desfesoterodine
- Dexetimide
- DIBD
- Dicycloverine (dicyclomine)
- Dihexyverine
- Difemerine
- Diphemanil metilsulfate
- Ditran
- Drofenine
- EA-3167
- EA-3443
- EA-3580
- EA-3834
- Emepronium bromide
- Etanautine
- Etybenzatropine (ethybenztropine)
- Fenpiverinium
- Fentonium bromide
- Fesoterodine
- Flavoxate
-
Glycopyrronium bromide (+beclometasone/formoterol, +indacaterol, +neostigmine)
- Hexahydrodifenidol
- Hexahydrosiladifenidol
- Hexbutinol
- Hexocyclium
- Himbacine
- HL-031,120
- Homatropine
- Imidafenacin
-
Ipratropium bromide (+salbutamol)
- Isopropamide
- J-104,129
- Hyoscyamine
- Mamba toxin 3
- Mamba toxin 7
- Mazaticol
- Mebeverine
- Meladrazine
- Mepenzolate
- Methantheline
- Methoctramine
- Methylatropine
- Methylhomatropine
- Methylscopolamine
- Metixene
- Muscarinic toxin 7
- N-Ethyl-3-piperidyl benzilate
- N-Methyl-3-piperidyl benzilate
- Nefopam
- Octatropine methylbromide (anisotropine methylbromide)
- Orphenadrine
- Otenzepad (AF-DX 116)
- Otilonium bromide
- Oxapium iodide
- Oxitropium bromide
- Oxybutynin
- Oxyphencyclimine
- Oxyphenonium bromide
- PBID
- PD-102,807
- PD-0298029
- Penthienate
- Pethidine
- pFHHSiD
- Phenglutarimide
- Phenyltoloxamine
- Pipenzolate bromide
- Piperidolate
- Pirenzepine
- Piroheptine
- Pizotifen
- Poldine
- Pridinol
- Prifinium bromide
- Procyclidine
- Profenamine (ethopropazine)
- Propantheline bromide
- Propiverine
- Quinidine
- 3-Quinuclidinyl thiochromane-4-carboxylate
- Revefenacin
- Rociverine
- RU-47,213
- SCH-57,790
- SCH-72,788
- SCH-217,443
- Scopolamine (hyoscine)
- Scopolamine butylbromide (hyoscine butylbromide)
- Silahexacyclium
- Sofpironium bromide
- Solifenacin
-
SSRIs (e.g., femoxetine, paroxetine)
- Telenzepine
- Terodiline
-
Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)
- Tiemonium iodide
- Timepidium bromide
- Tiotropium bromide
- Tiquizium bromide
- Tofenacin
- Tolterodine
-
Tricyclic antidepressants (e.g., amitriptyline (+perphenazine), amitriptylinoxide, butriptyline, cidoxepin, clomipramine, desipramine, desmethyldesipramine, dibenzepin, dosulepin (dothiepin), doxepin, imipramine, lofepramine, nitroxazepine, northiaden (desmethyldosulepin), nortriptyline, protriptyline, quinupramine, trimipramine)
- Tridihexethyl
- Trihexyphenidyl
- Trimebutine
- Tripitamine (tripitramine)
- Tropacine
- Tropatepine
- Tropicamide
- Trospium chloride
-
Typical antipsychotics (e.g., chlorpromazine, chlorprothixene, cyamemazine (cyamepromazine), loxapine, mesoridazine, thioridazine)
-
Umeclidinium bromide (+vilanterol)
- WIN-2299
- Xanomeline
- Zamifenacin
|
|
Precursors (and prodrugs)
|
|
|
|
nAChRs |
Agonists (and PAMs) |
- 5-HIAA
- 6-Chloronicotine
- A-84,543
- A-366,833
- A-582,941
- A-867,744
- ABT-202
- ABT-418
- ABT-560
- ABT-894
- Acetylcholine
- Altinicline
- Anabasine
- Anatabine
- Anatoxin-a
- AR-R17779
- Bephenium hydroxynaphthoate
- Butinoline
- Butyrylcholine
- Carbachol
- Choline
- Cotinine
- Cytisine
- Decamethonium
- Desformylflustrabromine
- Dianicline
- Dimethylphenylpiperazinium
- Epibatidine
- Epiboxidine
- Ethanol (alcohol)
- Ethoxysebacylcholine
- EVP-4473
- EVP-6124
- Galantamine
- GTS-21
- Ispronicline
- Ivermectin
- JNJ-39393406
- Levamisole
- Lobeline
- MEM-63,908 (RG-3487)
- Morantel
-
Nicotine (tobacco)
- NS-1738
- PHA-543,613
- PHA-709,829
- PNU-120,596
- PNU-282,987
- Pozanicline
- Pyrantel
- Rivanicline
- RJR-2429
- Sazetidine A
- SB-206553
- Sebacylcholine
- SIB-1508Y
- SIB-1553A
- SSR-180,711
- Suberyldicholine
- Suxamethonium (succinylcholine)
- Suxethonium (succinyldicholine)
- TC-1698
- TC-1734
- TC-1827
- TC-2216
- TC-5214
- TC-5619
- TC-6683
- Tebanicline
- Tribendimidine
- Tropisetron
- UB-165
- Varenicline
- WAY-317,538
- XY-4083
|
Antagonists (and NAMs) |
|
|
Precursors (and prodrugs)
|
|
|
|
|
α1 |
Agonists |
|
Antagonists |
- Abanoquil
- Ajmalicine
- Alfuzosin
- Anisodamine
- Anisodine
- Atiprosin
-
Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone)
- Benoxathian
-
Beta blockers (e.g., adimolol, amosulalol, arotinolol, carvedilol, eugenodilol, labetalol)
- Buflomedil
- Bunazosin
- Corynanthine
- Dapiprazole
- Domesticine
- Doxazosin
-
Ergolines (e.g., acetergamine, ergotamine, dihydroergotamine, lisuride, nicergoline, terguride)
- Etoperidone
- Fenspiride
- Hydroxyzine
- Indoramin
- Ketanserin
- L-765,314
- mCPP
- Mepiprazole
- Metazosin
- Monatepil
- Moxisylyte
- Naftopidil
- Nantenine
- Neldazosin
- Niaprazine
- Niguldipine
- Pardoprunox
- Pelanserin
- Perlapine
- Phendioxan
- Phenoxybenzamine
- Phentolamine
-
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)
- Piperoxan
- Prazosin
- Quinazosin
- Quinidine
- Silodosin
- Spegatrine
- Spiperone
- Talipexole
- Tamsulosin
- Terazosin
- Tiodazosin
- Tolazoline
-
Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin)
-
Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine)
- Trimazosin
-
Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Urapidil
- WB-4101
- Zolertine
|
|
α2 |
Agonists |
|
Antagonists |
- 1-PP
- Adimolol
- Amesergide
- Aptazapine
- Atipamezole
-
Atypical antipsychotics (e.g., asenapine, brexpiprazole, clozapine, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, zotepine)
-
Azapirones (e.g., buspirone, gepirone, ipsapirone, tandospirone)
- BRL-44408
- Buflomedil
- Cirazoline
- Efaroxan
- Esmirtazapine
- Fenmetozole
- Fluparoxan
- Idazoxan
- Ketanserin
- Lisuride
- mCPP
- Mianserin
- Mirtazapine
- NAN-190
- Pardoprunox
- Phentolamine
- Phenoxybenzamine
- Piperoxan
- Piribedil
- Rauwolscine
- Rotigotine
- Setiptiline
- Spegatrine
- Spiroxatrine
- Sunepitron
- Terguride
- Tolazoline
-
Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Yohimbine
|
|
β |
|
|
|
H1 |
Agonists |
|
Antagonists |
-
Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, brilaroxazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine)
-
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)
-
Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline)
-
Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine)
-
Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene)
|
|
H2 |
|
H3 |
|
H4 |
|
|
|
5-HT1 |
5-HT1A |
-
Agonists: 8-OH-DPAT
- Adatanserin
- Amphetamine
-
Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine)
-
Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, lurasidone, quetiapine, ziprasidone)
-
Azapirones (e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone)
- Bay R 1531
- Befiradol
- BMY-14802
- Cannabidiol
- Dimemebfe
- Dopamine
- Ebalzotan
- Eltoprazine
- Enciprazine
-
Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine (methylergonovine), methysergide, pergolide)
- F-11,461
- F-12826
- F-13714
- F-14679
- F-15063
- F-15,599
- Flesinoxan
- Flibanserin
- Flumexadol
- Hypidone
- Lesopitron
- LY-293284
- LY-301317
- mCPP
- MKC-242
- Naluzotan
- NBUMP
- Osemozotan
- Oxaflozane
- Pardoprunox
- Piclozotan
- Rauwolscine
- Repinotan
- Roxindole
- RU-24,969
- S-14,506
- S-14671
- S-15535
- Sarizotan
- Serotonin (5-HT)
- SSR-181507
- Sunepitron
-
Tryptamines (e.g., 5-CT, 5-MeO-DMT, 5-MT, bufotenin, DMT, indorenate, N-Me-5-HT, psilocin, psilocybin)
- TGBA01AD
- U-92,016-A
- Urapidil
- Vilazodone
- Xaliproden
- Yohimbine
|
-
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole)
- AV965
-
Beta blockers (e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, pindolol, propranolol, tertatolol)
- BMY-7,378
- CSP-2503
- Dotarizine
-
Ergolines (e.g., metergoline)
- FCE-24379
- Flopropione
- GR-46611
- Isamoltane
- Lecozotan
- Mefway
- Metitepine (methiothepin)
- MIN-117 (WF-516)
- MPPF
- NAN-190
- Robalzotan
- S-15535
- SB-649,915
- SDZ 216-525
- Spiperone
- Spiramide
- Spiroxatrine
- UH-301
- WAY-100135
- WAY-100635
- Xylamidine
|
|
|
5-HT1B |
-
Agonists: Anpirtoline
- CGS-12066A
- CP-93129
- CP-94253
- CP-122,288
- CP-135807
- Eltoprazine
-
Ergolines (e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
- mCPP
- RU-24,969
- Serotonin (5-HT)
-
Triptans (e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan)
- TFMPP
-
Tryptamines (e.g., 5-BT, 5-CT, 5-MT, DMT)
- Vortioxetine
|
|
|
|
5-HT1D |
-
Agonists: CP-122,288
- CP-135807
- CP-286601
-
Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide)
- GR-46611
- L-694247
- L-772405
- mCPP
- PNU-109291
- PNU-142633
- Serotonin (5-HT)
- TGBA01AD
-
Triptans (e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
-
Tryptamines (e.g., 5-BT, 5-CT, 5-Et-DMT, 5-MT, 5-(nonyloxy)tryptamine, DMT)
|
|
|
|
5-HT1E |
|
5-HT1F |
|
|
5-HT2 |
5-HT2A |
-
Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe, 25CN-NBOH, 2CBFly-NBOMe)
-
2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
- 2C-B-FLY
- 2CB-Ind
-
5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
-
α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
- AL-34662
- AL-37350A
- Bromo-DragonFLY
- Dimemebfe
- DMBMPP
-
DOx (e.g., DOB, DOC, DOI, DOM)
- Efavirenz
-
Ergolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergometrine (ergonovine), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, methylergometrine (methylergonovine), pergolide)
- Flumexadol
- IHCH-7113
- Jimscaline
- Lorcaserin
-
MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
- O-4310
- Oxaflozane
- PHA-57378
- PNU-22394
- PNU-181731
- RH-34
- SCHEMBL5334361
-
Phenethylamines (e.g., lophophine, mescaline)
-
Piperazines (e.g., BZP, quipazine, TFMPP)
- Serotonin (5-HT)
- TCB-2
- TFMFly
-
Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
-
Antagonists: 5-I-R91150
- 5-MeO-NBpBrT
- AC-90179
- Adatanserin
- Altanserin
-
Antihistamines (e.g., cyproheptadine, hydroxyzine, ketotifen, perlapine)
- AMDA
-
Atypical antipsychotics (e.g., amperozide, aripiprazole, asenapine, blonanserin, brexpiprazole, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine)
- Chlorprothixene
- Cinanserin
- CSP-2503
- Deramciclane
- Dotarizine
- Eplivanserin
-
Ergolines (e.g., amesergide, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
- Fananserin
- Flibanserin
- Glemanserin
- Irindalone
- Ketanserin
- KML-010
- Landipirdine
- LY-393558
- mCPP
- Medifoxamine
- Metitepine (methiothepin)
- MIN-117 (WF-516)
- Naftidrofuryl
- Nantenine
- Nelotanserin
- Opiranserin (VVZ-149)
- Pelanserin
- Phenoxybenzamine
- Pimavanserin
- Pirenperone
- Pizotifen
- Pruvanserin
- Rauwolscine
- Ritanserin
- Roluperidone
- S-14671
- Sarpogrelate
-
Serotonin antagonists and reuptake inhibitors (e.g., etoperidone, hydroxynefazodone, lubazodone, mepiprazole, nefazodone, triazoledione, trazodone)
- SR-46349B
- TGBA01AD
- Teniloxazine
- Temanogrel
-
Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
-
Tricyclic antidepressants (e.g., amitriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, setoperone, spiperone, spiramide, thioridazine, thiothixene, trifluoperazine)
- Volinanserin
- Xylamidine
- Yohimbine
|
|
|
5-HT2B |
-
Agonists: 4-Methylaminorex
- Aminorex
-
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine)
- BW-723C86
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Ergolines (e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
- Lorcaserin
-
MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
-
Piperazines (e.g., TFMPP)
- PNU-22394
- Ro60-0175
- Serotonin (5-HT)
-
Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
-
Antagonists: Agomelatine
-
Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, N-desalkylquetiapine (norquetiapine), N-desmethylclozapine (norclozapine), olanzapine, pipamperone, quetiapine, risperidone, ziprasidone)
- Cyproheptadine
- EGIS-7625
-
Ergolines (e.g., amesergide, bromocriptine, lisuride, LY-53857, LY-272015, mesulergine)
- Ketanserin
- LY-393558
- mCPP
- Metadoxine
- Metitepine (methiothepin)
- Pirenperone
- Pizotifen
- Propranolol
- PRX-08066
- Rauwolscine
- Ritanserin
- RS-127445
- Sarpogrelate
- SB-200646
- SB-204741
- SB-206553
- SB-215505
- SB-221284
- SB-228357
- SDZ SER-082
- Tegaserod
-
Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
- Trazodone
-
Typical antipsychotics (e.g., chlorpromazine)
- TIK-301
- Yohimbine
|
|
|
5-HT2C |
-
Agonists: 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
-
5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
-
α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
- A-372159
- AL-38022A
- Alstonine
- CP-809101
- Dimemebfe
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Ergolines (e.g., ALD-52, cabergoline, dihydroergotamine, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, pergolide)
- Flumexadol
- Lorcaserin
-
MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
- MK-212
- ORG-12962
- ORG-37684
- Oxaflozane
- PHA-57378
-
Phenethylamines (e.g., lophophine, mescaline)
-
Piperazines (e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP)
- PNU-22394
- PNU-181731
- Ro60-0175
- Ro60-0213
- Serotonin (5-HT)
-
Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
- Vabicaserin
- WAY-629
- WAY-161503
- YM-348
|
-
Antagonists: Adatanserin
- Agomelatine
-
Atypical antipsychotics (e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine)
- Captodiame
- CEPC
- Cinanserin
- Cyproheptadine
- Deramciclane
- Desmetramadol
- Dotarizine
- Eltoprazine
-
Ergolines (e.g., amesergide, bromocriptine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
- Etoperidone
- Fluoxetine
- FR-260010
- Irindalone
- Ketanserin
- Ketotifen
- Latrepirdine (dimebolin)
- Medifoxamine
- Metitepine (methiothepin)
- Nefazodone
- Pirenperone
- Pizotifen
- Propranolol
- Ritanserin
- RS-102221
- S-14671
- SB-200646
- SB-206553
- SB-221284
- SB-228357
- SB-242084
- SB-243213
- SDZ SER-082
- Tedatioxetine
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Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
- TIK-301
- Tramadol
- Trazodone
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Tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine)
- Xylamidine
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5-HT3–7
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5-HT3 |
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Agonists: Alcohols (e.g., butanol, ethanol (alcohol), trichloroethanol)
- m-CPBG
- Phenylbiguanide
-
Piperazines (e.g., BZP, mCPP, quipazine)
- RS-56812
- Serotonin (5-HT)
- SR-57227
- SR-57227A
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Tryptamines (e.g., 2-Me-5-HT, 5-CT, bufotenidine (5-HTQ))
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Volatiles/gases (e.g., halothane, isoflurane, toluene, trichloroethane)
- YM-31636
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Antagonists: Alosetron
- Anpirtoline
- Arazasetron
- AS-8112
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Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine)
- Azasetron
- Batanopride
- Bemesetron (MDL-72222)
- Bupropion
- Cilansetron
- CSP-2503
- Dazopride
- Dolasetron
- Galanolactone
- Granisetron
- Hydroxybupropion
- Lerisetron
- Memantine
- Ondansetron
- Palonosetron
- Ramosetron
- Renzapride
- Ricasetron
- Tedatioxetine
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Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
- Thujone
- Tropanserin
- Tropisetron
-
Typical antipsychotics (e.g., loxapine)
-
Volatiles/gases (e.g., nitrous oxide, sevoflurane, xenon)
- Vortioxetine
- Zacopride
- Zatosetron
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5-HT4 |
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5-HT5A |
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5-HT6 |
-
Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide)
- Hypidone
- Serotonin (5-HT)
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Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me-5-HT, ST-1936, tryptamine)
- WAY-181187
- WAY-208466
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Antagonists: ABT-354
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Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone)
- AVN-101
- AVN-211
- AVN-322
- AVN-397
- BGC20-760
- BVT-5182
- BVT-74316
- Cerlapirdine
- EGIS-12,233
- GW-742457
- Idalopirdine
- Ketanserin
- Landipirdine
- Latrepirdine (dimebolin)
- Masupirdine
- Metitepine (methiothepin)
- MS-245
- PRX-07034
- Ritanserin
- Ro 04-6790
- Ro 63-0563
- SB-258585
- SB-271046
- SB-357134
- SB-399885
- SB-742457
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Tetracyclic antidepressants (e.g., amoxapine, mianserin)
-
Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, nortriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, loxapine)
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5-HT7 |
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Antagonists: Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine)
- Butaclamol
- DR-4485
- EGIS-12,233
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Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
- JNJ-18038683
- Ketanserin
- LY-215,840
- Metitepine (methiothepin)
- Ritanserin
- SB-258719
- SB-258741
- SB-269970
- SB-656104
- SB-656104A
- SB-691673
- SLV-313
- SLV-314
- Spiperone
- SSR-181507
-
Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)
-
Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)
-
Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)
- Vortioxetine
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