RU-56187

RU-56187

Clinical data
Drug class	Nonsteroidal antiandrogen
Identifiers
IUPAC name 2-(Trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl)benzonitrile
CAS Number	143782-25-6
PubChem CID	132581
ChemSpider	117054
ChEMBL	ChEMBL1099140
CompTox Dashboard (EPA)	DTXSID90162545
Chemical and physical data
Formula	C14H12F3N3OS
Molar mass	327.33 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1(C(=O)N(C(=S)N1C)C2=CC(=C(C=C2)C#N)C(F)(F)F)C
InChI InChI=1S/C14H12F3N3OS/c1-13(2)11(21)20(12(22)19(13)3)9-5-4-8(7-18)10(6-9)14(15,16)17/h4-6H,1-3H3 Key:HLBUAKQNKJTEIU-UHFFFAOYSA-N

RU-56187 is a nonsteroidal antiandrogen which was never marketed. It shows 92% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors. The medication is a silent antagonist of the androgen receptor. RU-56187 is 3- to 10-fold more potent as an antiandrogen than bicalutamide or nilutamide in animals. Both RU-56187 and RU-58841 appear to be prodrugs of cyanonilutamide (RU-56279) in vivo in animals.

See also

• RU-57073
• RU-58642
• RU-59063