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Abandoned drugs
RU-58642
Другие языки:

RU-58642

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RU-58642
RU58642.svg
Clinical data
Drug class Nonsteroidal antiandrogen
Identifiers
  • 4-[3-(cyanomethyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C15H11F3N4O2
Molar mass 336.274 g·mol−1
3D model (JSmol)
  • O=C1N(CC#N)C(C)(C)C(=O)N1c(cc2C(F)(F)F)ccc2C#N
  • InChI=1S/C15H11F3N4O2/c1-14(2)12(23)22(13(24)21(14)6-5-19)10-4-3-9(8-20)11(7-10)15(16,17)18/h3-4,7H,6H2,1-2H3
  • Key:ZVWXHSNUBLIKJH-UHFFFAOYSA-N

RU-58642 is a nonsteroidal antiandrogen (NSAA) derived from nilutamide with very high affinity and selectivity for the androgen receptor (AR), which made it among the most potent and efficacious antiandrogens known at the time of its discovery. It was investigated for topical application for the treatment of androgenetic alopecia (male-pattern baldness), but development did not proceed past initial trial stages, and it is now only used for scientific research into the AR.

See also




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