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Selective androgen receptor modulator
S-23 (drug)
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    S-23 (drug)

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    S-23
    S-23.svg
    Legal status
    Legal status
    Identifiers
    • (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    Chemical and physical data
    Formula C18H13ClF4N2O3
    Molar mass 416.76 g·mol−1
    3D model (JSmol)
    • C[C@](COC1=CC(=C(C=C1)Cl)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
    • InChI=1S/C18H13ClF4N2O3/c1-17(27,9-28-12-4-5-14(19)15(20)7-12)16(26)25-11-3-2-10(8-24)13(6-11)18(21,22)23/h2-7,27H,9H2,1H3,(H,25,26)/t17-/m0/s1 ☒N
    • Key:SSFVOEAXHZGTRJ-KRWDZBQOSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.


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