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Mu-opioid receptor agonists
Sameridine
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    Sameridine

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    Sameridine
    Sameridine.svg
    Clinical data
    ATC code
    • none
    Identifiers
    • N-ethyl-1-hexyl-N-methyl-4-phenylpiperidine-4-carboxamide
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C21H34N2O
    Molar mass 330.516 g·mol−1
    3D model (JSmol)
    • O=C(N(CC)C)C2(c1ccccc1)CCN(CCCCCC)CC2
    • InChI=1S/C21H34N2O/c1-4-6-7-11-16-23-17-14-21(15-18-23,20(24)22(3)5-2)19-12-9-8-10-13-19/h8-10,12-13H,4-7,11,14-18H2,1-3H3 checkY
    • Key:TYWUGCGYWNSRPS-UHFFFAOYSA-N checkY
      (verify)

    Sameridine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine).

    Sameridine has an unusual pharmacological profile, being both a local anaesthetic and a μ-opioid partial agonist. It is currently under development for use in surgical anasthesia, mainly administered by intrathecal infusion. It produces less respiratory depression than morphine, even at a high dose, and produces no respiratory depression at a low dose.

    Sameridine is not currently a controlled drug, although if approved for medical use it will certainly be a prescription medicine, and it would probably be assigned to one of the controlled drug schedules in more restrictive jurisdictions such as Australia and the United States, especially if it were found to be addictive in animals.

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