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Mu-opioid receptor agonists
Semorphone
Другие языки:

    Semorphone

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    Semorphone
    Semorphone.svg
    Clinical data
    ATC code
    • none
    Identifiers
    • (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-methoxyethyl)morphinan-6-one
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C19H23NO5
    Molar mass 345.395 g·mol−1
    3D model (JSmol)
    • O=C4[C@@H]5Oc1c2c(ccc1O)C[C@H]3N(CC[C@]25[C@@]3(O)CC4)CCOC
    • InChI=1S/C19H23NO5/c1-24-9-8-20-7-6-18-15-11-2-3-12(21)16(15)25-17(18)13(22)4-5-19(18,23)14(20)10-11/h2-3,14,17,21,23H,4-10H2,1H3/t14-,17+,18+,19-/m1/s1 checkY
    • Key:PBGIBLLOMGURPS-GRGSLBFTSA-N checkY
      (verify)

    Semorphone (Mr 2264) is an opiate analogue that is an N-substituted derivative of oxymorphone.

    Semorphone is a partial agonist at μ-opioid receptors. It is around twice the potency of morphine, but with a ceiling effect on both analgesia and respiratory depression which means that these effects stop becoming any stronger after a certain maximum dose.

    It is not currently used in medicine, and is not a controlled drug, although it might be considered to be a controlled substance analogue of oxymorphone on the grounds of its related chemical structure in some jurisdictions such as the United States, Canada, Australia and New Zealand.


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