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Abandoned drugs
Triphenylmethylethylene
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    Triphenylmethylethylene

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    Triphenylmethylethylene
    Triphenylmethylethylene.png
    Clinical data
    Other names Methyltriphenylethylene; Triphenylpropene
    Drug class Nonsteroidal estrogen
    Identifiers
    • 1,1-diphenylprop-1-en-2-ylbenzene
    CAS Number
    PubChem CID
    ChemSpider
    Chemical and physical data
    Formula C21H18
    Molar mass 270.375 g·mol−1
    3D model (JSmol)
    • CC(=C(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3
    • InChI=1S/C21H18/c1-17(18-11-5-2-6-12-18)21(19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,1H3
    • Key:FLTIZNYOOOPPHQ-UHFFFAOYSA-N

    Triphenylmethylethylene, also known as methyltriphenylethylene or as triphenylpropene, is a synthetic nonsteroidal estrogen of the triphenylethylene group that is related to triphenylchloroethylene and was never marketed. Along with diethylstilbestrol and triphenylchoroethylene, triphenylmethylethylene was studied in 1944 by Sir Alexander Haddow for the treatment of breast cancer, and this is historically notable in that it was the first time that high-dose estrogens were found to be effective in the treatment of breast cancer. However, while diethylstilbestrol and triphenylchloroethylene were found to be significantly effective, triphenylmethylethylene was less effective and showed a favorable response in only 1 of 4 treated cases.

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