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Human drug metabolites
8-Hydroxyamoxapine
Другие языки:

    8-Hydroxyamoxapine

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    8-Hydroxyamoxapine
    Chemical structure of 8-Hydroxyamoxapine
    Pharmacokinetic data
    Elimination half-life 30 hours
    Identifiers
    • 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepin-3-ol
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEBI
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C17H16ClN3O2
    Molar mass 329.78 g·mol−1
    3D model (JSmol)
    • C1CN(CCN1)C2=NC3=C(C=CC(=C3)O)OC4=C2C=C(C=C4)Cl
    • InChI=1S/C17H16ClN3O2/c18-11-1-3-15-13(9-11)17(21-7-5-19-6-8-21)20-14-10-12(22)2-4-16(14)23-15/h1-4,9-10,19,22H,5-8H2
    • Key:QDWNOKXUZTYVGO-UHFFFAOYSA-N

    8-Hydroxyamoxapine is an active metabolite of the antidepressant drug amoxapine (Asendin). It contributes to amoxapine's pharmacology. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) with similar norepinephrine, but more serotonin, reuptake inhibition as its parent compound. It plays a part in balancing amoxapine's ratio of serotonin to norepinephrine transporter blockage.

    See also


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