Ketipramine

Ketipramine

Clinical data
Routes of administration	Oral
ATC code	none
Identifiers
IUPAC name 5-[3-(dimethylamino)propyl]-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one
CAS Number	796-29-2 Y Fumarate salt: 17243-32-2 Y
PubChem CID	28424
ChemSpider	26443
UNII	U5C4H63K5U Fumarate salt: 86490E9X8J Y
CompTox Dashboard (EPA)	DTXSID60229790
Chemical and physical data
Formula	C19H22N2O
Molar mass	294.398 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C3c1c(cccc1)N(c2c(cccc2)C3)CCCN(C)C

Ketipramine (G-35,259), also known as ketimipramine or ketoimipramine, is a tricyclic antidepressant (TCA) that was tested in clinical trials for the treatment of depression in the 1960s but was never marketed. It differs from imipramine in terms of chemical structure only by the addition of a ketone group, to the azepine ring, and is approximately equivalent in effectiveness as an antidepressant in comparison.

It was one of the drugs prescribed by Roland Kuhn in a series of unethical experiments to test drugs on children without informed consent and without proper approval at the psychiatric hospital in Münsterlingen, Switzerland.

See also

• Tricyclic antidepressant