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Mu-opioid receptor agonists
AD-1211
Другие языки:

    AD-1211

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    AD-1211
    AD-1211 2D.svg
    Clinical data
    Other names AD-1211
    ATC code
    • none
    Identifiers
    • 1-(3-Methyl-2-butenyl)-4-[(1R)-1-phenyl-2-(3-hydroxyphenyl)ethyl]piperazine
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C23H30N2O
    Molar mass 350.506 g·mol−1
    3D model (JSmol)
    • c1c(O)cccc1CC(c3ccccc3)N(CC2)CCN2C\C=C(\C)/C
    • InChI=1S/C23H30N2O/c1-19(2)11-12-24-13-15-25(16-14-24)23(21-8-4-3-5-9-21)18-20-7-6-10-22(26)17-20/h3-11,17,23,26H,12-16,18H2,1-2H3/t23-/m1/s1 checkY
    • Key:WLHCNEPBQJOHKW-HSZRJFAPSA-N checkY
      (verify)

    AD-1211 is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-prenyl-piperazine derivative, which is structurally unrelated to most other opioid drugs. The (S)-enantiomers in this series are more active as opioid agonists, but the less active (R)-enantiomer of this compound, AD-1211, is a mixed agonist–antagonist at opioid receptors with a similar pharmacological profile to pentazocine, and has atypical opioid effects with little development of tolerance or dependence seen after extended administration in animal studies.

    See also



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