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Mu-opioid receptor agonists
Diphenpipenol
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    Diphenpipenol

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    Diphenpipenol
    Diphenpipenol Structure.svg
    Clinical data
    ATC code
    • None
    Identifiers
    • 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethyl]phenol
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C25H28N2O2
    Molar mass 388.511 g·mol−1
    3D model (JSmol)
    • COc4ccccc4N1CCN(CC1)C(Cc2cccc(O)c2)c3ccccc3
    • InChI=1S/C25H28N2O2/c1-29-25-13-6-5-12-23(25)26-14-16-27(17-15-26)24(21-9-3-2-4-10-21)19-20-8-7-11-22(28)18-20/h2-13,18,24,28H,14-17,19H2,1H3
    • Key:ILCZMFSACNEMGK-UHFFFAOYSA-N

    Diphenpipenol is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative related to compounds such as MT-45 and AD-1211, but diphenpipenol is the most potent compound in the series, with the more active (S) enantiomer being around 105 times the potency of morphine in animal studies. This makes it a similar strength to fentanyl and its analogues, and consequently diphenpipenol can be expected to pose a significant risk of producing life-threatening respiratory depression, as well as other typical opioid side effects such as sedation, itching, nausea and vomiting.

    Diphenpipenol has been offered for sale online as a designer drug, though analysis of a sample of supposed diphenpipenol found it to instead contain a structural isomer with much weaker opioid activity, and it is unclear if genuine diphenpipenol has actually been sold.

    Alternate isomer sold as diphenpipenol

    See also


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